Recent studies have shown that there are serious adverse drug interactions with the use of various medications containing CBD, including Marinol (Marinol ER), Syndros (Syntagren), Carafate (Tenex) and others. These medications contain a chemical called CBD, which is found in high amounts in hemp and marijuana and can only be obtained from these sources if they are processed into usable forms. CBD is one of nature’s most powerful anti-psychotic drugs, and is also commonly used to treat people with epilepsy. However, it has not been scientifically proven that it is an effective treatment for schizophrenia or bipolar disorder, despite some reports to this effect.
CBD and other plant cannabinoids are known to interact with many common pharmaceuticals by reducing the action of another enzyme – cytochrom P450. Therefore, the potential risks of CBD oil may be mainly explained by drug interactions involving CYP450 enzymes. These enzymes help metabolize the many different chemical substances that enter our bodies. They can break down both drugs and plant-based compounds into their simpler forms, allowing us to safely take them. When an individual takes more than the recommended dose of a medication containing CBD, for instance, there can result in a build up of CBD in the blood, and this may inhibit the action of the other drugs or compound substances that were included in the medication.
In fact, one of the most common drug interactions involving CBD is related to a specific family of drugs called benzodiazepines. This class of drugs includes such substances as Ativan and Xanax, but it is especially important to note that these drugs are commonly combined with CBD. Since benzodiazepines include the enzyme gamma-aminobutyric acid (GABA), which helps in the central nervous system, it may reduce the ability of CBD to interact with the enzyme. When both drugs are present in combination, this interaction may increase the side effects of the CBD while also increasing the side effects of the benzodiazepine. Because CBD is generally thought to have no harmful side effects, it is essential that individuals who suffer from psychiatric disorders are careful when combining it with benzodiazepines to ensure they get the maximum benefit from CBD and minimize the risk of potential harmful interactions.